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Remembrances
11:34 am
Thu July 19, 2012

Fresh Air Remembers Actress Celeste Holm

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Originally published on Thu July 19, 2012 12:44 pm

Celeste Holm, the actress of stage and screen, passed away of a heart attack on July 15. She was 95 years old.

Made famous on Broadway for her role as Ado Annie in Rodgers and Hammerstein's Oklahoma!, Holm earned more fans for her performances in All About Eve (1950), The Tender Trap (1955) and High Society (1956).

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Shots - Health Blog
11:30 am
Thu July 19, 2012

How HIV Hijacks The Immune System

Next imagePrevious image
Credit Courtesy of Ivan Konstantinov / © Visual Science 2011
A 3-D model of HIV peeled back to show its layers. HIV's genetic material sits inside a spherical shell (gray matrix) studded with spikes (dark gray and orange). The sphere pops open when a T cell tugs on a spike.
Credit Courtesy of Ivan Konstantinov, Yury Stefanov, Alexander Kovalevsky, Yegor Voronin / © Visual Science 2011
A 3D model of HIV pealed back to show its layers. HIV is like a jack-in-the-box. Its genetic material sits inside a spherical shell (gray matrix) studded with spikes (dark gray and orange). The sphere pops open when a T cell tugs on a spike.
Credit Sriram Subramaniam and Donald Bliss / PLoS Pathogens
HIV is thought to originate from Simian Immunodeficiency Virus, also known as the African Green Monkey virus. As for HIV, the genes of SIV are encased in a shell with spikes that help it invade a cell. This 3-D model was obtained by cryo-electron tomography.
Credit Sriram Subramaniam and Donald Bliss / Nature
On the left, one HIV spike sits on the virus's surface, ready to interact with an immune cell. When finger-like projections on T cells bind to the spike,the virus bursts open and releases its genes into the cell. Current gene therapies prevent this interaction.
Credit Courtesy of Sriram Subramaniam and Donald Bliss / NIH
An artistic rendition of an immune cell, illustrating the petal-like sheets on its surface.
Credit Sriram Subramaniam and Donald Bliss / PLoS Pathogens
HIV particles--the red spheres--pool in deep canyons and tubes within the surface of an immune cell. Some scientist think that HIV can spread quickly around the immune system by hiding out in these nooks and crannies.
Credit Courtesy of Sriram Subramaniam / NIH
test
Credit Courtesy of Sriram Subramaniam and Donald Bliss / NIH
HIV—red circles—have two strategies for shuttling around the immune system. It can infect T cells (yellow) directly, and it can hide out in the nooks and crannies of other immune cells (pink), waiting for a T cell to reach in and grab it. This image was obtained by electron tomography.
Credit Courtesy of Ivan Konstantinov / © Visual Science 2011
A 3D model of HIV pealed back to show its layers. HIV is like a jack-in-the-box. Its genetic material sits inside a spherical shell (gray matrix) studded with spikes (dark gray and orange). The sphere pops open when a T cell tugs on a spike.
Credit Sriram Subramaniam and Donald Bliss / PLoS Pathogens
HIV is thought to originate from Simian Immunodeficiency Virus, also known as the African Green Monkey virus. As for HIV, the genes of SIV are encased in a shell with spikes that help it invade a cell. This 3-D model was obtained by cryo-electron tomography.
Credit Sriram Subramaniam and Donald Bliss / Nature
One HIV spike sits on the virus's surface, ready to interact with an immune cell. When finger-like projections on T cells, such as CCR5, bind to the spike, the virus bursts open and releases its genes into the cell. Current gene therapies prevent this interaction.
Credit Courtesy of Sriram Subramaniam / NIH
Here the HIV spike--represented by the wire frame--connects with the CCR5 receptor--turquoise balls. CCR5 sits on the surface of T cells. When it engages with the HIV spike, the HIV shell pops open and release the virus's genes into the T cell. Current gene therapies protect T cells from infection by disrupting the CCR5 gene.
Credit Courtesy of Sriram Subramaniam and Donald Bliss / NIH
An artistic rendition of an immune cell, illustrating the petal-like sheets on its surface.
Credit Sriram Subramaniam and Donald Bliss / PLoS Pathogens
HIV particles--the red spheres--pool in deep canyons and tubes within the surface of an immune cell. Some scientist think that HIV can spread quickly around the immune system by hiding out in these nooks and crannies.
Credit Sriram Subramaniam and Donald Bliss / Nature
On the left, one HIV spike sits on the virus's surface, ready to interact wih --represented by the wire frame--connects with the CCR5 receptor--turquoise balls. CCR5 sits on the surface of T
Credit Courtesy of Ivan Konstantinov / © Visual Science 2011
A 3-D model of HIV peeled back to show its layers. HIV's genetic material sits inside a spherical shell (gray matrix) studded with spikes (dark gray and orange). The sphere pops open when a T cell tugs on a spike.
Credit Sriram Subramaniam and Donald Bliss / PLoS Pathogens
HIV is thought to originate from simian immunodeficiency virus, also known as the African Green Monkey virus. As for HIV, the genes of SIV are encased in a shell with spikes that help it invade a cell. This 3-D model was obtained by cryo-electron tomography.
Credit Courtesy of Sriram Subramaniam / Nature
On the left, one HIV spike seen on the virus' surface. When it bumps into a T cell, a finger-like projection on the cell's surface, called CCR5, pushes down on the spike. This interaction pops open the HIV and releases the infectious genes into the cell. A gene therapy could protect T cells by inactivating the CCR5 gene.
Credit Courtesy of Sriram Subramaniam and Donald Bliss / NIH
An artistic rendering of an immune cell, illustrating the petal-like sheets on its surface.
Credit Sriram Subramaniam and Donald Bliss / PLoS Pathogens
HIV particles (red spheres) pool in deep crevices on the surface of an immune cell. Some scientist think that HIV can move quickly around the immune system by hiding out in these nooks and crannies.
Credit Courtesy of Sriram Subramaniam and Donald Bliss / NIH
Here a T cell (yellow) reaches into the surface of another immune cell (pink) to grab HIV particles (red circles). This image was obtained by electron tomography.
Credit Courtesy of Sriram Subramaniam and Donald Bliss / NIH
HIV--the red circles--has two strategies for shuttling around the immune system. It directly infects T cells (yellow), and it hides out on the surface of other cells (pink), waiting for a T cell to reach in and pick it up. This 3-D model is obtained from electron tomography.
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Originally published on Tue July 24, 2012 4:23 pm

The road to a cure for AIDS is in sight, even if every step on the journey isn't clear yet.

One of the most promising avenues is a kind of gene therapy that would block HIV's entry into cells of the immune system. A genetic tweak could make these key cells resistant to the virus's attack.

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The Salt
10:54 am
Thu July 19, 2012

Romney And Jimmy John's Sandwiches, Never Far Apart

Credit Steven Depolo / Flickr.com
Jimmy John's sandwiches, wrapped and ready to go.
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Jimmy John's Gourmet Sandwiches are a big part of Republican presidential candidate Mitt Romney's campaign. The story of the sandwich chain founder's success is now a regular part of the Romney stump speech, and, according to our political correspondent Ari Shapiro, "It's a reliable bet that almost any time the Romney press bus provides lunch, it will be a big box of Jimmy John's subs."

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NPR Story
10:38 am
Thu July 19, 2012

Bill Bellamy: Full Throttle Family Man, Funny Man

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Originally published on Thu July 19, 2012 8:53 pm

Transcript

MICHEL MARTIN, HOST:

I'm Michel Martin and this is TELL ME MORE from NPR News. We're continuing our series called Make Me Laugh. All summer long we're talking to some of the country's most popular entertainers, who have brought their unique comedy styles to film, television and standup.

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Politics
10:38 am
Thu July 19, 2012

Are Romney Critics Really Attacking His Success?

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Originally published on Thu July 19, 2012 10:47 am

Republican presidential candidate Mitt Romney's tenure at Bain Capital and his refusal to release more extensive tax records continue to dog his campaign. Host Michel Martin takes up these topics and other political news of the week with Republican strategist Ron Christie and Joy-Ann Reid, managing editor of The Grio.com.

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